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KMID : 0624620230560070404
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BMB Reports
2023 Volume.56 No. 7 p.404 ~ p.409
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The impact of cancer cachexia on gut microbiota composition and short-chain fatty acid metabolism in a murine model
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Jeong Seung-Min
Jin Eun-Ju
Shibo Wei
Bae Ju-Hyeon
Ji Yo-Sep
Jo Yun-Ju
Jeong Jee-Heon
Im Se-Jin
Ryu Dong-Ryeol
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Abstract
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This study investigates the relationship between cancer cachexia and the gut microbiota, focusing on the influence of cancer on microbial composition. Lewis lung cancer cell allografts were used to induce cachexia in mice, and body and muscle weight changes were monitored. Fecal samples were collected for targeted metabolomic analysis for short chain fatty acids and microbiome analysis. The cachexia group exhibited lower alpha diversity and distinct beta diversity in gut microbiota, compared to the control group. Differential abundance analysis revealed higher Bifidobacterium and Romboutsia, but lower Streptococcus abundance in the cachexia group. Additionally, lower proportions of acetate and butyrate were observed in the cachexia group. The study observed that the impact of cancer cachexia on gut microbiota and their generated metabolites was significant, indicating a host-to-gut microbiota axis.
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KEYWORD
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16s amplicon sequencing, Cancer cachexia, Gut microbiome, Muscle atrophy, Short-chain fatty acids (SCFA)
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